The HLA B5701 Strip test allows the determination of the HLA B5701 alleles.


Since the introduction of combined antiretroviral therapy, HIV infection has gone from being a serious and fatal disease to one which is chronic but controllable. Antiretroviral therapy usually entails combining 2 nucleosides which are analogous to reverse transcriptase inhibitors and either an HIV protease inhibitor or a non-nucleoside reverse transcriptase inhibitor. These drugs are very effective but they are associated with a series of undesired effects, such as severe hypersensitivity reactions, especially in the case of therapies using abacavir or nevirapine.

Abacavir is used in the treatment of HIV-1 infection since 1999. The WHO recommends abacavir as a second-line treatment, owing to the risk of hypersensitivity associated with its use, which affects 5-8 % of Caucasian patients.

Several studies have demonstrated the existence of a strong predictive correlation, in Caucasian populations and groups of Hispanic ethnicity, between hypersensitivity to abacavir and the presence of the HLA-B5701 allele. This correlation is strong enough to enable us to predict the risk of hypersensitivity to abacavir and classify individuals as low (<1%) or high (>70 %) risk, based on the absence or presence of the HLA-B5701 allele.

Several polymorphisms has been identified. These ones explain nearly 15 % of the variability in HIV-1 viral load in individuals during the asymptomatic phase of the disease were identified. One of them, located in the HCP5 gene (HLA complex P5), shows a perfect linkage disequilibrium with HLA-B5701 (r2 = 1)..


The useful role of this SNP in predicting hypersensitivity to abacavir has been demonstrated in European populations (100 % detection sensitivity for HLA-B5701, specificity of 99.4 %, positive predictive value of 94.2 % and negative predictive value of 100 %).


Leave A Comment

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Pellentesque imperdiet purus quis metus imperdiet fermentum. Suspendisse hendrerit id lacus id lobortis. Morbi accumsan nulla ac urna elementum dapibus. Phasellus eu felis orci, sit amet placerat eros. Sed aliquet iaculis nisi id convallis. Quisque nec ligula ut felis hendrerit iaculis quis sed neque.

Security code